Safety Concerns: Aluminum in Vaccines

Updated 6/1/2015

International Journal of ‪Alzheimers‬ Disease 2011: Link between Aluminum and the Pathogenesis of Alzheimer’s Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses

“Whilst being environmentally abundant, aluminum is not essential for life. On the contrary, aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically important functions and causes various adverse effects in plants, animals, and humans.”

Presentation on March 26, 2014 at International Symposium on Vaccines in Nice, France: A Role for the Pineal Gland in Neurological Damage Following Aluminum-adjuvanted Vaccination (Powerpoint Slides) (PDF Versionhttp://people.csail.mit.edu/seneff/SeneffNice2014.pdf

Pharmacology & Toxicology, 1992: http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0773.1992.tb00471.x/abstract 

“Aluminium is widely used as an adjuvant in human vaccines, and children can often receive up to 3.75 mg of parenteral aluminium during the first six months of life. We show that intraperitoneal injection of aluminium adsorbed vaccines into mice causes a transient rise in brain tissue aluminium levels peaking around the second and third day after injection. This rise is not seen in the saline control group of animals or with vaccine not containing aluminium. It is likely that aluminium is transported to the brain by the iron-binding protein transferrin and enters the brain via specific transferrin receptors.”

Toxicological Profile for Aluminum – US Agency for Toxic Substances and Disease Registry (PDF)

Intestinal Absorption of Aluminum – see: http://ndt.oxfordjournals.org/content/17/suppl_2/13.full.pdf

“No known physiologic need exists for aluminum; however, because of its atomic size and electric charge (0.051 nm and 3+, respectively), it is sometimes a competitive inhibitor of several essential elements of similar characteristics, such as magnesium (0.066 nm, 2+), calcium (0.099 nm, 2+), and iron (0.064 nm, 3+). At physiological pH, aluminum forms a barely soluble Al(OH)3 that can be easily dissolved by minor changes in the acidity of the media.[2]

Approximately 95% of an aluminum load becomes bound to transferrin and albumin intravascularly and is then eliminated renally. In healthy subjects, only 0.3% of orally administered aluminum is absorbed via the GI tract and the kidneys effectively eliminate aluminum from the human body. It is only when the GI barrier is bypassed, such as intravenous infusion or in the presence of advanced renal dysfunction, that aluminum has the potential to accumulate. As an example, with intravenously infused aluminum, 40% is retained in adults and up to 75% is retained in neonates.[4]” – http://emedicine.medscape.com/article/165315-overview

Study from Canada in April 2013 Cell Biology & Toxicology:
How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale http://link.springer.com/article/10.1007%2Fs10565-013-9239-0

“Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and neurological disorder. In this review, we outline how this intracellular generator of reactive oxygen species (ROS) triggers a metabolic shift towards lipogenesis in astrocytes and hepatocytes. This Al-evoked phenomenon is coupled to diminished mitochondrial activity, anerobiosis, and the channeling of α-ketoacids towards anti-oxidant defense. The resulting metabolic reconfiguration leads to fat accumulation and a reduction in ATP synthesis, characteristics that are common to numerous medical disorders. Hence, the ability of Al toxicity to create an oxidative environment promotes dysfunctional metabolic processes in astrocytes and hepatocytes. These molecular events triggered by Al-induced ROS production are the potential mediators of brain and liver disorders.”

ALUMUNIUM MEDIATED OXIDATIVE STRESS: POSSIBLE RELATIONSHIP TO COGNITIVE IMPAIRMENT OF ALZHEIMERS TYPE, Annals of Neurosciences, Vol 13, No 1 (2006)

1953: Alum causes Epilepsy in the Monkey Following Multiple Intracerebral Injections (Bull N Y Acad Med.)

1994 STUDY: Internal load of aluminum suggested “disturbing effects” on short-term memory, learning, and attention. – Read more here.

CHOP-alumPhoto credit: Vaccine “Education” Center – Children’s Hospital of PA.


July 10, 2013

According to the CDC, aluminum gels or salts of aluminum are added as adjuvants to “help promote an earlier, more potent response, and more persistent immune response to the vaccine.” CDC then links us to a “What you Need to Know” document from the Vaccine Education Center at The Children’s Hospital of Philadelphia which aims to assure the reader that aluminum is perfectly safe, comparable even to breastfeeding your baby.

These claims of perfect safety are at odds with current research on the subject.

Firstly, aluminum is a known neurotoxin. In 2011, Masahiro Kawahara and Midori Kato-Negishi wrote in the International Journal of Neurotoxicology that,

“…it is widely accepted that Al is a recognized neurotoxin, and that it could cause cognitive deficiency and dementia when it enters the brain and may have various adverse effects on CNS. In general, the absorption of metals by the gastrointestinal tract is widely variable and is influenced by various factors including an individual difference, age, pH, stomach contents [173]. Recent studies using mass spectrometry of 26Al have demonstrated that small, but a considerable amount of Al crosses the blood brain barrier, enters into the brain, and accumulates in a semipermanent manner [174, 175]. Therefore, Al can cause severe health problems in particular populations, including infants, elderly people, and patients with impaired renal functions, and unnecessary exposure to Al should be avoided for such patients [176].Now, newly published research by Keele Conference scientists shows that aluminum adjuvant in vaccines transfers to the brain. Intramuscular injection of alum-containing vaccine was associated with the appearance of aluminum deposits in distant organs, such as spleen and brain where they were still detected one year after injection.” (page 14)

Secondly, recent research suggests that aluminum is linked to neurotoxicity and even dementia (Immunologic Research, online April 23, 2013). Aluminum is found in higher concentrations in the brains of Alzheimers patients (Journal of Alzheimers Disease, online, Jan. 1, 2013). There is growing concern that aluminum is involved in the development of Alzheimer’s (Clinical Biochemistry, Jan. 2013).

The path of aluminum adjuvant from injection site to the brain was documented in a mouse model this year (see:Slow CCL2-dependent translocation of biopersistent particles from muscle to brain.” – and Read more in this article by Heidi Stevenson.

Sayer Ji wrote, “Can We Continue To Justify Injecting Aluminum Into Children?” which is also an essential read on this subject.

Nuclear Aluminum (JR Walton)
Nuclear Aluminum (JR Walton)

*Photo Credit / See also:

Aluminum in hippocampal neurons from humans with Alzheimer’s disease.”

May 29, 2013

Dear Concerned Vermonter for Vaccine Choice,

Today a bill, “To Encourage Transparency in Disclosing of the Ingredients in Vaccinations for Children” passed the Maine House and will move to the Senate (tomorrow, May 30, 2013). This bill requires healthcare workers to disclose ingredients in vaccines to parents and to remind parents of their right to refuse vaccination.

This is a model bill for Vermont if ever I saw one.  There is nothing quite like the sinking feeling that a mother or father may have after consenting to baby’s “routine immunizations,” only to then experience an adverse reaction and to later learn what was in those shots.  We all have to make informed choices and do what we feel is best for our kids – but no doubt it is better to have all the facts up front.

Please read the bill here and consider sharing with your Senator(s) and Representative(s).

Also of interest: 

  • May 19, 2013: A Wisconsin bill would ban mandatory flu shots; Legislation was drafted after several hospital workers and health care contractors complained they were fired after refusing to be vaccinated. Read more here.
  • May 20, 2013: The Supreme Court ruled unanimously that patients filing vaccine injury lawsuits can still get attorneys’ fees if the case is, “brought in good faith and (for which) there was a reasonable basis.” AP coverage here; Full SCOTUS ruling is available here, and the Amicus Curiae brief (including our coalition), is available, here.

 

~ Jennifer Stella, Vermont Coalition for Vaccine Choice

Pertussis Vaccine, Background

Oct. 2, 2013

In 1997, the CDC published a report titled, Pertussis Vaccination: Use of Acellular Pertussis Vaccines Among Infants and Young Children Recommendations of the Advisory Committee on Immunization Practices (ACIP). In this report they clearly state that, “The increase in reported pertussis cases has occurred despite pertussis vaccination coverage levels that are higher than at any time in the past.”

Today, we are experiencing outbreaks of whooping cough. Is it groundhog day all over again?

Today, whole cell pertussis vaccine (DPT vaccine) is not administered in the US.

Of all the vaccines which have been routinely used by children in the past century, the brain damaging effects of the pertussis (whooping cough) portion of DPT vaccine is among the most well documented in the scientific literature. Created in 1912, the crude pertussis vaccine basically consisted of B. pertussis bacteria killed with heat, preserved with formaldehyde, and injected into children. In the early 1940’s, aluminum was added as an adjuvant and later the mercury preservative, thimerosal, was added when pertussis was combined with diphtheria and tetanus vaccines to create DPT. Pertussis vaccine was never studied in large clinical trials before being given to children in the first half of the 20th century or after it was combined into DPT and recommended for mass use by the American Academy of Pediatrics in 1947.

The pertussis vaccine’s ability to kill was first signaled in 1933 when T. Madsen reported two babies died within minutes of vaccination. In 1947, Matthew Brody gave detailed descriptions of two cases involving brain damage and death after pertussis vaccination. But, it was the 1948 published case study by Byers and Moll that gave the strongest warning that children were suffering brain inflammation within 72 hours of pertussis vaccination and being left with various kinds of brain damage. Forty years later, the prospective UCLA/FDA study published in Pediatrics in 1981 comparing DT and DPT vaccines would find that 1 in 875 DPT shots is followed by either a convulsion or collapse shock episode within 48 hours of vaccination.

Biological mechanisms for pertussis vaccine induced brain damage center on pertussis toxin (PT), one of the most lethal toxins in nature. Pertussis toxin is a known neurotoxin, a reliable inducer of brain inflammation and brain damage, which is why it is used in lab animals to deliberately induce EAE (experimental autoimmune encephalomyelitis). Pertussis toxin is implicated in brain inflammation caused by pertussis (whooping cough) complications as well as pertussis vaccine complications. Unfortunately, pertussis toxin is also thought to be responsible for stimulating immunity which is why it remains in DPT, DTaP and Tdap vaccines.. Other ingredients in DPT vaccine, which have been associated with neuroimmune dysfunction and may interact synergistically with pertussis toxin to cause shock, brain damage or death are: endotoxin, aluminum, and mercury.

After decades of reports in the medical literature that the pertussis portion of DPT vaccine was causing brain damage in some children, the large, case controlled National Childhood Encephalopathy Study was conducted in Britain and published in 1981. It confirmed a statistically significant association between pertussis vaccine or pertussis-containing vaccines (DPT) and acute brain inflammation leading to permanent brain damage. An NCES reanalysis 10 years later re-confirmed the finding. In 1994, the Institute of Medicine, National Academy of Sciences, published a report validating the conclusions of NCES, stating that ” “the balance of evidence is consistent with a causal relation between DPT and the forms of chronic nervous system dysfunction in the NCES in those children who experience a serious acute neurological illness within 7 days after receiving DPT vaccine.”

A Ten-Year High for Vaccine Injury Filings in 2013, according to Acting Director of Division of Vaccine Injury Compensation, Vito Caserta.

http://www.hrsa.gov/vaccinecompensation/accvmeetingbookmarch2013.pdf

“He added that the majority of claims filed are filed by adults, mainly associated with injuries alleged to have been caused by influenza vaccine.”

source: www.NVIC.org

The Hazards of Aluminum

Published in Voice of America by Julie Taboh, April 29, 2013.

“Aluminum is everywhere. From airplanes to cooking pans, this versatile, light-weight metal has been around for generations. And its many benefits have made life easier and more convenient for millions of people. But a new documentary portrays what the filmmaker describes as the “dark side” of aluminum.

It’s in the cans we drink out of and in the products we like to cook with.

Aluminum is everywhere, including in products that make us feel better, safer and cleaner. Like antacids, sunscreen and antiperspirants.

But Austrian filmmaker Bert Ehgartner says there’s another side to aluminum. “It has a lot of good plus[es]. But there is also a dark side of this metal,” he said.

Ehgartner explores that alleged “dark side” in his new film, The Age of Aluminum.

The documentary shows the mining and production of aluminum and its resulting impact on the environment.

One sees the mining of bauxite, an ore that contains a large amount of aluminum hydroxide, from a rainforest in Brazil. The film shows how large areas of rain forest have to be dug up in order to reach the bauxite.

The toxic waste from aluminum production is then discarded over vast areas.

And according to the film, the mining waste is apparently causing health problems for the nearby inhabitants who swim in the water, drink it and cook with it. The children complain of itchy skin and have developed blisters.

The film also includes footage of a 2010 accident at a Hungarian aluminum factory.

Ehgartner says aluminum is also making people sick, in other ways – through the very products that make life more convenient, and safer, for so many.

“I was surprised, for example, when I found it in vaccines or when I found it in certain kinds of cosmetics and antiperspirants, even in foods. You find it everywhere,” he said.

Scientists in the film link aluminum found in those products to a wide variety of modern diseases, including breast cancer, Alzheimer’s, allergies and Autism.

Neuroscientist Dr. Christopher Shaw is particularly concerned about the link between aluminum, which can be found in drinking water and antacid medication, and Alzheimer’s, a fatal brain-wasting disease.

“Many researchers are beginning to accept that aluminum has some sort of role to play in neurodegenerative diseases such as Alzheimer’s. Whether it does in others is still an open question, but Alzheimer’s is really coming into focus and it’s fairly clear that the body burden of aluminum from all the sources to which humans are exposed may be contributing to Alzheimer’s disease,” he said.

But not everyone agrees with those findings.

The Aluminum Association declined our request for an interview but issued the following statement:

The Age of Aluminum deviates from decades of mainstream scientific research and consensus. The weight of published scientific evidence demonstrates no direct causative link between aluminum and the illnesses depicted in the film.

“My first message would be don’t panic,” said Melissa Perry, an epidemiologist at The George Washington University School of Public Health and Health Services.

“The current status of the evidence does not give us definitive conclusions that aluminum is linked to Alzheimer’s disease or other brain problems, or breast cancer. This means it’s critically important to conduct more human studies,” she added.

More studies – that’s a point on which even The Age of Aluminum filmmaker Bert Ehgartner agrees.

“So aluminum is really a threat for mankind and we don’t have enough research, and that’s one of the reasons why I made this film – to give support to the scientists who want to do more research. And I think it’s really necessary,” he said.

Experts on both sides of the issue agree that aluminum is here to stay. They also agree that what is needed, at the very least, is more research to understand the link between aluminum and human health.”

2012 data indicate that Alzheimer’s Disease is a human form of chronic Aluminum neurotoxicity – see International Journal of Alzheimers Disease, 2012.