SSPE

Highly Recommended Reading: Subacute sclerosing panencephalitis and measles vaccination.

What is it? http://www.researchgate.net/publication/17386802_Subacute_sclerosing_panencephalitis_measles_encephalitis_of_temperate_evolution

Can the vaccine cause it? Package Insert: “There have been reports of subacute sclerosing panencephalitis (SSPE) in children who did not have a history of infection with wild-type measles but did receive measles vaccine. Some of these cases may have resulted from unrecognized measles in the first year of life or possibly from the measles vaccination. Based on estimated nationwide measles vaccine distribution, the association of SSPE cases to measles vaccination is about one case per million vaccine doses distributed.” http://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf

PE Dr. Tautz
Measles vaccination and SSPE

A commentary by Dr. med. Christoph Tautz , leading pediatrician and the Children’s Hospital at the Gemeinschaftskrankenhaus Herdecke (originally published here).

Reports that have been recently circulating about a six-year-old boy who has SSPE (Subacute Sclerosing Panencephalitis) have had an impact on the discussion on whether it is good or bad to vaccinate against the measles.

When this child, who lived near Bielefeld, Germany, was five years old he had caught the measles in a pediatrician’s practice from a child who had not been vaccinated. In late 2004 he started showing the first symptoms of encephalitis which was diagnosed as SSPE. Since then the child’s condition has deteriorated continuously.

The question as to the frequency of this fatal complication of measles cannot be answered with certainty. It used to be that one assumed 1 to 5 cases of SSPE for each 1 million cases of measles. In the context of a recent trial at the Institut für Virologie at the University of Wuerzberg, Germany, however, 5 to 10 cases per year were observed which amounts to 120 cases since 1988. It cannot be determined how frequent this fatal complication actually is, as there was no obligation to report the measles until 2000 and therefore the total number of people who had contracted the measles is not known in Germany.

Not only have these questions remained unanswered. The question as to what causes SSPE has not been answered yet either. Why the viruses linger in the brain and destroy the tissue there in some people and not in most people have not been clarified yet. What seems to be clear is that the younger the children are the greater the probability of contracting SSPE is.

Regarding the assumed increase in SSPE cases it must be asked whether they are not to be seen in connection with the recommended vaccination strategy, either directly or indirectly.
As a result of the increase in applied measle vaccinations the number of complications and thus the number of SSPE cases should actually go down and not got up, as reported from Wuerzburg

The question arises for the boy mentioned above: How could he have been protected as a baby?
On the one hand at five months he was too young, thus at best an existing maternal passive immunity from the mother’s antibodies should have protected him from SSPE. But to be able to do this she would have had to have had measles when she was a child. If, however, the mother was vaccinated against the measles when she was a child and there was no chance to boost the vaccination protection through contact with wild viruses she was not able to provide maternal passive immunity for her child as an adult. Thus the infection of the baby with measles and SSPE later on is an indirect consequence of the measle vaccination the mother had and thus of the general vaccination strategy.

On the other hand contagion could have been prevented if the older child had not had measles thanks to a vaccination. The reports to not state whether this child had been vaccinated or whether the child had been vaccinated and the vaccination had failed and the child had thus contracted the measles. Or whether there were reasons not to vaccinate the child, possibly because of too few antibodies or severe neurodermatitis.

It continues to be propagated that vaccinations can protect from SSPE. However, this complication also occurs in people who have been vaccinated, albeit less frequently. Furthermore it has been suspected that children who have undergone the measles without anyone noticing so that they were vaccinated (and, as the recommendation goes, twice!) have a special disposition and are in danger of developing SSPE later. (1)

The statement that the measles could be eradicated as a result of consistent mass vaccinations is more and more questionable, due to the fact that a rate of 90-95% vaccinations, which is today’s vaccination strategy, is not even achievable when there are 10% primary and 5-10% secondary vaccination failures. There is the risk that there will be an ever greater number of non-immune adults who could expect even more severe complications than small children if the contract the measles.

In view of this complex situation there should be detailed and transparent consultations, the goal of which must remain that the individual can decide for themselves whether they want to be vaccinated or not as an expression of responsibility for oneself and the responsibility towards society.

Dr. med. Christoph Tautz
Pediatrician
Kinderklinik am Gemeinschaftskrankenhaus Herdecke

Have there been reported cases after vaccination?

– CDC report: “As of July 1982, 634 individuals suspected of having SSPE, with onset from 1956-1981, had been reported to the registry; of these, 368 were U.S. citizens who met the case definition of SSPE and had onset of symptoms between 1969 and 1981 (Figure 1). Fifty-five percent (202) of the 368 confirmed cases had a history of only measles infection; 14% (51) had a history of only measles vaccination; and 17% (63) had a history of both, with the natural illness most frequently preceeding the vaccination. The remaining 14% (52) gave no positive history of having natural measles infection or measles vaccination.” http://www.cdc.gov/mmwr/preview/mmwrhtml/00001185.htm

– 1994 IOM review: “SSPE is a recognized sequela of measles infection, and it is biologically plausible that it could occur after administration of the live attenuated viral vaccine. Identification of the cause of SSPE as wild-type or vaccine-strain measles virus has not been possible. The viruses isolated from patients with SSPE differ from the known measles viruses. The viruses may have become altered by the prolonged residence in the brains of the patients, or they may have been different at the time of the original infection.” http://www.nap.edu/openbook.php?record_id=2138&page=136

– Searchable Reported Events: http://www.medalerts.org/vaersdb/findfield.php?TABLE=ON&GROUP1=AGE&EVENTS=ON&SYMPTOMS[]=Subacute+scl
erosing+panencephalitis+%2810042297%29

More information: http://www.whale.to/vaccines/sspe1.html

Official Regulatory position: “inadequate evidence either to reject or accept any causal relationship” http://www.who.int/vaccine_safety/committee/topics/measles_sspe/Jul_2005/en/index.html

And today, uninformed parents play the blame game and (unwittingly?) help to hide the truth, that there is “another side” to this story: http://justthevax.blogspot.co.uk/2013/06/micha-is-dead.html