Learn more about ‪PANDAS‬ (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococci), with information from Miroslav Kovacevic, MD FAAP, by clicking here.

(5) Characteristic clinical presentation.
– Sudden (sometimes overnight) onset of symptoms. Parents frequently recall the exact date and/or time of the day when symptoms appeared.
– Wax-and-wane pattern of symptoms. Symptoms exacerbation is frequently associated with or may occur following an infectious event and/or administration of certain vaccines. Even without the treatment there may be partial improvement in symptoms within 4 – 6 weeks. Unfortunately, certain symptoms (especially the separation anxiety) will persist even during these periods.
– The initial episode may be associated with GABHS infection, however subsequent episodes do not necessarily have to be related to GABHS. CAUTION: association of PANDAS and GABS appears to be more than casual, however firm evidences supporting the exclusive role of GABS in pathophysiology of PANDAS is currently lacking